Pathogenesis and Disease Mechanisms of Occupational Asthma
نویسندگان
چکیده
منابع مشابه
Pathogenesis of occupational asthma.
The development of occupational asthma (OA) is likely to result from the complex interaction of environmental and host factors. This article addresses a series of issues relating to the multiple environmental factors that could affect the initiation of OA, including the intrinsic characteristics of causative agents, as well as the influence of the level, mode and route of exposure. Although the...
متن کاملMechanisms of occupational asthma.
BACKGROUND The pathogenesis and the pathologic alterations of occupational asthma are similar to those of nonoccupational asthma. Occupational asthma may therefore represent a useful model of "human asthma" to investigate mechanisms and pathophysiology of asthma in general. In an occupational setting the cause and onset of asthma may be easily identified, and the natural history may be examined...
متن کاملMechanisms and pathology of occupational asthma.
Since the pathogenesis and the pathological features of occupational asthma are similar to those of nonoccupational asthma, the former represents a very useful model for the investigation of the pathogenesis of asthma in general. More than one mechanism may be operative in occupational asthma. Among the mechanisms proposed, immunological mechanisms and airway inflammation play an important role...
متن کاملPolyQ disease pathogenesis mechanisms
481 June 2012, Vol. 102, No. 6 SAMJ Polyglutamine (polyQ) diseases are inherited neurodegenerative conditions caused by expansion of a coding trinucleotide CAG repeat, which is translated into an abnormally long polyQ tract in the mutant protein.1 There are currently 9 known polyQ diseases: Huntington disease (HD), dentatorubral-pallidoluysian atrophy (DRPLA), spinal bulbar muscular atrophy (SB...
متن کاملMechanisms of Gaucher disease pathogenesis.
Gaucher disease is caused by mutations in the Gba1 gene encoding an acid β-glucocerebrosidase (GBA1), the lysosomal hydrolase which breaks down glucosylceramide (GlcCer). In Gaucher type 1 disease the accumulation of this simple glycolipid is mainly restricted to tissue phagocyte lysosomes resulting ultimately in hepatomegaly, splenomegaly and osteopenia. Lower residual GBA1 levels leads to neu...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Immunology and Allergy Clinics of North America
سال: 2011
ISSN: 0889-8561
DOI: 10.1016/j.iac.2011.07.008